Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair.
Cells – November 26, 2025
Source: PubMed Central
Summary
Psychedelics offer intriguing prospects for Multiple Sclerosis, potentially fostering neuroimmune modulation and repair. Early investigations suggest certain compounds can reduce neuroinflammation by up to 40% in preclinical models, while others show promise in enhancing neuroplasticity. With over a dozen distinct psychedelic compounds under exploration, their unique mechanisms, often involving serotonin receptors, could lead to therapies addressing both symptom management and disease progression. Navigating regulatory and safety challenges remains crucial for advancing these novel treatments for MS.
Abstract
Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair.