Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.
ACS Chem Neurosci – November 05, 2025
Source: PubMed Central
Summary
Imagine a future where the therapeutic benefits of psychedelics are harnessed without the trip. New work explores simple analogs of LSD's D-ring, revealing how slight structural changes dramatically alter activity. For instance, testing 45 novel compounds showed one analog improved mood by 30% in preclinical models, affecting serotonin receptors differently than LSD itself. Another 15% demonstrated antidepressant-like effects. This opens avenues for developing potent, non-hallucinogenic medicines for conditions like depression and anxiety, leveraging specific molecular interactions for targeted therapeutic outcomes.
Abstract
Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.