A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers.
Br J Pain – September 04, 2025
Source: PubMed Central
Summary
Microdosing lysergic acid diethylamide (LSD) at 15 µg significantly blunted pain perception, offering a potential new avenue for pain management. A randomised, placebo-controlled investigation with 40 healthy volunteers found participants experienced a 25% reduction in pain intensity. This suggests a single low dose of LSD can alter how the brain processes discomfort. The findings highlight the therapeutic potential of carefully administered psychedelics, warranting further exploration into their mechanisms and broader applications for chronic pain conditions.
Abstract
A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers.