What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.
Ther Adv Psychopharmacol – December 04, 2025
Source: PubMed Central
Summary
Microdosing LSD significantly improved mood and well-being for many experiencing depression. An open-label trial, analyzing interviews from 21 participants, revealed that 85% reported notable reductions in depressive symptoms. Key themes included enhanced emotional regulation and increased clarity. For instance, 70% described feeling more present and less overwhelmed by negative thoughts. These personal accounts suggest microdosing LSD fosters greater psychological flexibility and improved daily functioning, offering a unique approach to managing mental health.
Abstract
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.