Associations between psychedelic use and adverse outcomes in substance use disorders: a real-world EHR-based cohort study.
Front Psychiatry – October 24, 2025
Source: PubMed Central
Summary
Psychedelic use appears surprisingly safe for individuals with substance use disorders. An analysis of 65,321 electronic health records revealed that prior psychedelic use was not linked to a higher risk of adverse events like overdose or psychiatric crises. In fact, individuals reporting psychedelic use showed a 15% lower likelihood of hospitalization for certain substance-related complications compared to non-users. This large-scale data challenges common assumptions, suggesting psychedelics may not exacerbate risks for those struggling with addiction.
Abstract
Associations between psychedelic use and adverse outcomes in substance use disorders: a real-world EHR-based cohort study.