In Vivo and in Vitro Chromosomal Damage Induced by LSD-25

Summary

Lysergic acid diethylamide (LSD) has been shown to induce chromosomal aberrations in human leukocytes, marking it as a significant chemical of interest. In a study involving 6 healthy individuals, in vitro analyses revealed that LSD can cause notable chromosomal changes. This adds to the understanding of how psychotomimetic substances interact with genetic material, potentially informing future pharmacological applications and implications for genetic neurodegenerative diseases. The findings highlight the intersection of biology, medicine, and biochemical analysis in assessing drug effects on human cells.

Abstract

THE induction of chromosomal aberrations by exogenous agents, such as viruses, radiation and chemicals, is an area of active cytogenetic investigation.1 Recently, the psychotomimetic hallucinogen, lysergic acid diethylamide (LSD-25), has been added to the list of chemicals capable of causing abnormalities in the chromosomes of human leukocytes.2 , 3 Such preliminary studies report the in vitro and in vivo chromosomal effects of LSD, and the present communication extends these observations to include additional in vitro findings and a significant sample of patients.Materials and MethodsIn Vitro StudiesPeripheral leukocyte cultures were initiated from 6 normal, healthy persons (3 males and 3 . . .

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