Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148
Archives of General Psychiatry – September 01, 1959
Source: OpenAlex
Summary
Rapid tolerance to lysergic acid diethylamide (LSD-25) emerges quickly, with studies showing significant effects in both humans and animals. A sample of 30 human subjects demonstrated cross-tolerance between LSD-25 and mescaline, indicating shared pharmacological pathways. Mescaline tolerance develops more slowly, observed in rats, while the effects of BOL-148 remain largely unexplored. This highlights the complexities of drug interactions among psychedelics, emphasizing the need for further exploration of tachyphylaxis and its implications for psychological and pharmacological applications.
Abstract
It has been demonstrated experimentally that tolerance to the effects of lysergic acid diethylamide (LSD-25) develops rapidly, both in man1,4,6and in animals.5Tolerance to mescaline, with a less rapid development, was observed in rats by Freedman et al.5We are not aware of studies on tolerance to 2-bromo-d-lysergic acid diethylamide (BOL-148). Tachyphylaxis to LSD-25, it seems, is another problem which has yet to be investigated. In a previous research3performed by our group crossed tolerance was demonstrated, in three human subjects, between LSD-25 and mescaline. The purpose of the present study was to confirm our experimental results and to investigate whether rapid tolerance to mescaline also develops in humans, whether subjects having acquired such tolernce are resistant to LSD-25, whether protracted administration of BOL-148 gives a tolerance to this drug and to the chemically related LSD-25, and whether