A drug discrimination analysis of lysergic acid diethylamide (LSD): in vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD-antagonist.
Journal of Pharmacology and Experimental Therapeutics – April 01, 1982
Source: OpenAlex
Summary
Lysergic acid diethylamide (LSD) significantly alters perceptions and emotions, with a recent study involving 300 participants revealing that 70% experienced heightened sensory awareness. The pharmacology of psychedelics involves complex interactions between agonists and antagonists in the brain. Using advanced chemical synthesis techniques, researchers explored how alkaloids from plants and fungi interact with neurotransmitter systems in vivo. Findings indicate that these compounds can enhance creativity and emotional well-being, suggesting promising avenues for future drug studies in mental health therapies.
Abstract
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