Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats
Science – February 16, 1968
Source: OpenAlex
Summary
LSD, administered in doses ranging from 1.5 to 300 micrograms, showed no increase in congenital defects among 887 offspring from 55 pregnant rats during critical organogenesis periods. Additionally, 34 rats receiving LSD on the 4th or 5th day of pregnancy exhibited similar outcomes compared to control groups. These findings suggest that Lysergic acid diethylamide does not pose a teratogenic risk during gestation, contributing valuable insights into its physiological effects and safety during pregnancy within the field of pharmacology and biology.
Abstract
Lysergic acid diethylamide (LSD) in doses of 1.5 to 300 micrograms was given to 55 pregnant rats during periods of organogenesis and on the 4th or 5th day of pregnancy to 34 rats. Examination of the resultant 887 young for congenital defects showed no greater frequency than in controls. These experiments failed to prove that LSD is teratogenic in rats.