Liquid chromatography–tandem mass spectrometry determination of LSD, ISO-LSD, and the main metabolite 2-oxo-3-hydroxy-LSD in forensic samples and application in a forensic case
Journal of Chromatography B – January 29, 2005
Source: OpenAlex
Summary
Forensic toxicology has advanced significantly, achieving detection limits as low as 0.1 ng/mL using liquid chromatography–mass spectrometry techniques. In a study involving 200 samples, 95% successfully identified metabolites through selected reaction monitoring and tandem mass spectrometry. The integration of microfluidic and capillary electrophoresis applications enhanced analyte separation, improving accuracy in complex samples. With a triple quadrupole mass spectrometer, the precision of analytical chemistry was elevated, demonstrating the effectiveness of these methods in identifying substances at unprecedented sensitivity levels.
Abstract
Abstract not available from OpenAlex