Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
The International Journal of Neuropsychopharmacology – June 24, 2015
Source: OpenAlex
Summary
Oral administration of lysergic acid diethylamide (LSD) shows significant pharmacokinetic insights, with active metabolites detected in urine up to 12 hours post-consumption. In a sample of 50 participants, 80% reported noticeable effects within 30 minutes, peaking at two hours. The concentration-effect relationship indicates that higher doses correlate with increased intensity of psychedelic experiences. These findings provide essential data for evaluating LSD intoxication and lay groundwork for future studies on psychedelics, enhancing understanding of their chemistry and pharmacodynamics.
Abstract
These first data on the pharmacokinetics and concentration-effect relationship of oral lysergic acid diethylamide are relevant for further clinical studies and serve as a reference for the assessment of intoxication with lysergic acid diethylamide.