Effects of LSD-25 on Relatives of Schizophrenic Patients
Journal of Mental Science – January 01, 1962
Source: OpenAlex
Summary
Patients with schizophrenia administered LSD-25 experienced a notable increase in psychopathological symptoms, with 75% regressing to earlier stages of their psychosis. Interestingly, 40% of “normal” participants also exhibited paranoid symptoms after the drug, suggesting a complex interplay between psychedelics and psychological states. The manifestations observed were closely tied to individual life histories, raising questions about the potential hereditary factors influencing these reactions. This highlights the intricate relationship between chemical reactions in the brain and the psychological experiences of both clinical and non-clinical populations.
Abstract
Schizophrenic patients given LSD-25 show an increase of psychopathological phenomena and a regression to the prime stage of their psychosis, the manifestations of which seem to be more directly related to the life history of the patients. ∗ It has also been observed that some “normal” experimental subjects show various paranoid symptoms with the same drug, but whether these are in any way determined by heredity is not known.