Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro
Life Sciences – June 01, 1998
Source: OpenAlex
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly alter dopamine receptor activity, impacting behavior. In a study involving 120 participants, those administered LSD showed a 30% increase in dopamine levels compared to a placebo group. This rise in dopamine was linked to heightened prolactin levels, suggesting that psychedelics act as agonists on the dopamine receptor D2. Additionally, biochemical analysis revealed that spiperone, a dopamine antagonist, effectively blocked this effect. These findings illuminate the complex interaction between neurotransmitters and behavior within pharmacology and endocrinology.
Abstract
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