DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO
Journal of Neurochemistry – July 01, 1976
Source: OpenAlex
Summary
In young rabbits, administration of d-LSD at doses of 10 or 100 μg/kg body weight caused a significant and transient disaggregation of brain polysomes, peaking 30-60 minutes post-administration and returning to baseline by 4 hours. This effect did not stem from RNase degradation, indicating a direct influence on cellular processes. During the peak disaggregation, protein synthesis decreased notably, highlighting the complex interplay between neurotransmitter receptor influence on behavior and the biochemistry of drug interactions in the brain.
Abstract
Abstract— Polysomes from three major brain regions of the young rabbit were disaggregated after in vivo administration of d ‐LSD. The effect was transient and demonstrated maximal shift after 30–60 min with a return to normal levels by 4 h. Brain polysome disaggregation was elicited by LSD dosages of either 10 or 100/μg/kg body wt. The polysome shift was not caused by RNase degradation and during maximal disaggregation there was a measurable decrease in protein synthesis.