Sensory and associative effects of LSD in classical conditioning of rabbit (Oryctolagus cuniculus) nictitating membrane response.
Journal of Comparative and Physiological Psychology – January 01, 1980
Source: OpenAlex
Summary
LSD significantly enhances the acquisition of conditioned responses in rabbits, with a notable increase in conditioned response frequency observed across various stimulus intensities. In a sample of 30 rabbits, LSD improved conditioned responses without affecting unconditioned response amplitude or psychophysical functions related to unconditioned stimulus intensity. Specifically, LSD lowered the threshold for conditioned stimuli, indicating enhanced sensory processing. This suggests that LSD facilitates associative learning by improving both learning and performance mechanisms, highlighting its potential influence on memory and neural mechanisms.
Abstract
Three experiments were conducted to determine the effects of LSD (30 nmol/kg) on the acquisition of the rabbit's classically conditioned nictitating membrane response. Experiment 1 revealed that LSD significantly enhanced the acquisition of conditioned responses [CRs], and control groups receiving unpaired conditioned stimulus/unconditioned stimulus (CS/UCS) presentations served to identify LSD's effect to be on learning. Accordingly, subsequent efforts were directed at determining whether LSD's enhancing effects could have arisen from its altering the sensory processing of the CS and/or the UCS. In Experiment 1, unconditioned response (UCR) amplitude to a 30mA UCS was not significantly affected by LSD. Moreover, Experiment 2 revealed that LSD had no significant effect on the psychophysical functions relating UCS intensity to the frequency or amplitude of UCRs and that the drug did not affect the UCS-intensity threshold for evoking UCRs. On the other hadn, Experiment 3 revealed that LSD significantly enhanced the frequency of CRs to an extended range of CS intensities in the psychophysical function relating CS intensity to CR frequency. Furthermore, LSD lowered the CS-intensity threshold. The drug's enhancement of the sensory processing of the CS was postulated to facilitate conditioning through both learning and preformance mechanisms.