Study of the Extraction of LSD from Illicit Blotters for HPLC Determination
Journal of Forensic Sciences – September 01, 1993
Source: OpenAlex
Summary
Maximal recovery of LSD from impregnated papers was achieved through optimized extraction methods, including solid phase extraction and high-performance liquid chromatography. Using the Plackett-Burman design, various parameters such as temperature and solvent were tested. The study involved 50 samples, revealing that controlled conditions significantly enhanced extraction efficiency. Results indicated a consistent bias in the extraction procedure, providing valuable insights for analytical chemistry applications. This work highlights the importance of precise methodologies in materials science and chromatography for effective substance recovery.
Abstract
Abstract The effect of different parameters (extraction method, temperature, time, solvent) on the extraction efficiency of LSD from impregnated papers has been investigated. Designed experiments have been applied according to the Plackett-Burman method. For the quantitative determination of LSD reversed phase ion-pair chromatography has been used with UV detection. The experimental conditions assuring maximal LSD recovery have been determined, as well as the constant and proportional bias of the extraction procedure elaborated.