LSD and 9,10‐dihydro‐LSD Analyses in Street Drug Blotter Samples via Easy Ambient Sonic‐Spray Ionization MassSpectrometry (EASI‐MS)
Journal of Forensic Sciences – August 06, 2012
Source: OpenAlex
Summary
A new method using easy ambient sonic-spray ionization mass spectrometry (EASI (+)‐MS) successfully identified LSD and its new variant, 9,10-dihydro-LSD, in seized blotters. Out of 41 samples tested, 68% contained LSD, while 17% revealed the presence of 9,10-dihydro-LSD. Six samples tested negative for both substances. This advanced technique, combined with thin layer chromatography, offers a powerful and straightforward approach for drug detection in forensic laboratories, enhancing the reliability of analytical chemistry in identifying designer drugs.
Abstract
Abstract Normally, the identification of the LSD drug is performed by forensic laboratories, using the E hrlich spot test. However, this is a nonspecific analysis. Additionally, the Brazilian Federal Police has identified the presence of a new compound in seized blotters: 9,10‐dihydro‐ LSD , an uncontrolled substance. In this work, easy ambient sonic‐spray ionization mass spectrometry in the positive ion mode, EASI (+)‐ MS , was used to characterize LSD and 9,10‐dihydro‐ LSD compositions directly from the surface of blotters. The presence of LSD in the seized blotter samples were also confirmed via high‐performance liquid chromatography with ultraviolet detector. In a set of 41 blotters analyzed by EASI (+)‐ MS , 28 showed positive results for LSD , seven for 9,10‐dihydro‐ LSD , and another six samples showed negative results for both LSD and 9,10‐dihydro‐ LSD . The combination of thin layer chromatography with EASI ‐ MS also demonstrated to be a relatively simple and powerful screening tool for forensic analysis of street drugs.