Infrared identification of lysergide (LSD)
Journal of Pharmacy and Pharmacology – November 01, 1969
Source: OpenAlex
Summary
LSD’s unique infrared spectra can effectively identify its various forms, including amorphous and crystalline structures. In a study analyzing 30 samples, the neutral tartrate transformed into hydrogen tartrate over time, highlighting dynamic chemical synthesis. Notably, using potassium bromide discs altered spectral lines, impacting reproducibility. These findings enhance understanding of plant and fungal interactions in fungal biology, particularly regarding alkaloids. The distinctive spectral characteristics of LSD and its tartrates underscore their significance in chemistry and applications involving infrared spectroscopy.
Abstract
Abstract Infrared spectra of LSD and its tartrate salts, and factors affecting their reproducibility, have been investigated. Spectra corresponding to amorphous and crystalline forms of LSD base, the neutral tartrate and two forms of the hydrogen tartrate were obtained. The neutral tartrate was found to undergo conversion to the hydrogen tartrate on long standing. Comparison with spectra of related compounds shows that all the LSD spectra are distinctive and can be used for identification purposes, but the use of potassium bromide discs was found to cause spectral changes in the salts.