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Toxic Effect of Stramonium Simulating LSD Trip

Joseph N. Digiacomo

JAMA April 15, 1968 DOI: 10.1001/jama.1968.03140160075025

Summary

Ingesting Datura stramonium, as seen in four teenage cases linked to Asthmador powder, can mimic LSD reactions. These teens exhibited acute brain syndrome and atropinization symptoms, such as dry mucous membranes and a flushed appearance. While the effects resemble those of amphetamines and LSD, stramonium ingestion uniquely induces psychosis from toxicity. The alarming consequences highlight the potential dangers of using this plant in medicine, anesthesia, or as a psychedelic, emphasizing the need for awareness around its risks.

Abstract

Four cases of stramonium poisoning in teen-agers secondary to ingestion of Asthmador asthmatic powder (stramonium-belladonna mixture) presented as LSD reactions. The clinical manifestations were acute brain syndrome and physical signs of atropinization. The effects of stramonium ingestion are similar to the effects of the ingestion of amphetamine and LSD, but in addition to the psychosis due to toxic reaction, the patient who has ingested stramonium typically has dry mucous membranes and is hot and flushed.

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