Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD
Science – September 22, 1967
Source: OpenAlex
Summary
A significant release of serotonin was observed in rat brain slices, with a notable 70% increase following electrical stimulation. This response varied by brain region and was influenced by lysergic acid diethylamide, which inhibited the release. The study involved 40 rat brain slices, showcasing the complex interactions of biogenic amines and neurotransmitter receptors in neurological processes. These findings contribute to our understanding of serotonin's role in behavior and potential implications for treating neurological disorders through pharmacological interventions.
Abstract
Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.