Klinefelter's syndrome, LSD usage and acute lymphoblastic leukemia
Clinical Genetics – July 01, 1974
Source: OpenAlex
Summary
A 19-year-old male with Klinefelter syndrome and a history of LSD use developed acute lymphoblastic leukemia, raising concerns about the interplay between genetic predispositions and environmental factors. The case highlights potential cytogenetic injuries linked to LSD exposure, which may have exacerbated the effects of his chromosomal abnormalities. This intersection of genetic and clinical aspects underscores the importance of understanding how genomic variations can influence cancer susceptibility, particularly in individuals with existing disorders related to sexual differentiation.
Abstract
A 19‐year‐old boy, with Klinefelter's syndrome and a history of LSD usage, developed acute lymphoblastic leukemia. The possibility is discussed that this was caused by cytogenetic injuries subsequent to LSD exposure and the inherited chromosomal anomaly acting in concert.