Comparison of tetrahydrocannabinol and synhexyl in man
Clinical Pharmacology & Therapeutics – November 01, 1968
Source: OpenAlex
Summary
A synthetic isomer of tetrahydrocannabinol showed notable effects when tested against a semisynthetic THC-like compound, synhexyl. In a study with 16 volunteers, doses of THC ranged from 341 to 946 µg/kg (median 581), while 13 subjects received synhexyl at doses from 633 to 2,666 µg/kg (median 1,370). Both drugs produced similar clinical syndromes, yet synhexyl’s onset was slower and only one-third as potent. Participants experienced lasting euphoria and pronounced dreamlike sequences, differing from LSD in sedation and physiological responses.
Abstract
A synthetic isomer of tetrahydrocannabinol (1‐Δ'‐3,4‐transtetrahydrocannabinol), believed to be identical to the most active naturally occurring THC, was compared with a semisynthetic THC‐like compound, synhexyl. Sixteen volunteer subiects received THC in doses ranging from 341 to 946 p.g per kilo gram (median 581). Thirteen subjects received synhexyl in doses ranging from 633 to 2,666 µg per kilogram (median 1,370). Clinical syndromes tram the 2 drugs were similar, although synhexyl was slower in onset and only about one third as potent. The clinical effects resembled those of psychotomimetics such as LSD, at least at the higher doses. These drugs differed from LSD in the following respects: sedation was prominent; euphoria was langer lasting; dreamlike sequences more pronounced; and physiological and biochemical effects were somewhat different, especially in the absence of sympathomimetic effects.