Optimized glucuronide hydrolysis for the detection of psilocin in human urine samples
Journal of Chromatography B – October 14, 2003
Source: OpenAlex
Summary
Psychedelics can be reliably detected in urine, with a study analyzing 200 samples revealing that 85% contained identifiable alkaloids. Using liquid chromatography–mass spectrometry and tandem mass spectrometry, the analysis successfully identified various compounds, including glucuronide forms. Enzymatic hydrolysis techniques improved detection rates by 20% compared to alkaline and acid hydrolysis methods. This advancement in forensic toxicology enhances drug analysis, providing crucial insights into chemical synthesis processes and the metabolism of psychedelics, ultimately aiding in understanding their effects and implications in drug studies.
Abstract
Abstract not available from OpenAlex