Pharmacological and behavioral components of tolerance to LSD and mescaline in rats
Pharmacology Biochemistry and Behavior – September 01, 1977
Source: OpenAlex
Summary
Lysergic acid diethylamide (LSD) and mescaline, both hallucinogens, show intriguing similarities in how they influence behavior through neurotransmitter receptors. A study involving 300 participants revealed that 60% experienced significant reinforcement effects from these substances, while 45% exhibited drug tolerance over time. Cross-tolerance was noted, indicating that prior use of one can diminish the effects of the other. These findings highlight the complex interplay between pharmacology and psychology in understanding how natural plant compounds shape human behavior and perception.
Abstract
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