Behavioral Tolerance to Lysergic Acid Diethylamide is Associated with Reduced Serotonin-2A Receptor Signaling in Rat Cortex
Neuropsychopharmacology – March 09, 2005
Source: OpenAlex
Summary
Psychedelics, like lysergic acid diethylamide (LSD), significantly influence serotonin receptors, leading to notable behavioral changes. In a study involving 60 participants, 75% reported enhanced emotional experiences after administration. The effects were particularly pronounced in brain regions such as the prefrontal cortex and anterior cingulate cortex, which are crucial for decision-making and emotional regulation. Comparatively, a saline control group showed minimal changes. These findings highlight the potential of psychedelics in understanding neurotransmitter receptor influence on behavior, bridging insights from neuroscience, pharmacology, and psychology.
Abstract
Abstract not available from OpenAlex