The confirmation and quantitation of LSD in urine using gas chromatography/mass spectrometry
Rapid Communications in Mass Spectrometry – January 01, 1993
Source: OpenAlex
Summary
LSD can now be detected and quantified at an impressive sensitivity of 10 picograms per milliliter using advanced gas chromatography-mass spectrometry techniques. This innovative method requires only a quarter of the sample size compared to earlier approaches, significantly improving efficiency. Additionally, it enhances column longevity by minimizing the use of derivatizing agents. With a focus on analytical chemistry and chromatography, this breakthrough in mass spectrometry applications offers a more effective way to analyze substances like LSD in urine samples.
Abstract
Abstract Confirmation and quantitation of LSD, as its trimethyI silyI derivative, is carried out using a commercial gas chromatography/mass spectrometry system. The method uses 4 times less sample than previous methods, extends column life by reducing the amount of derivatizing agent used and can detect and quantify LSD at the 10 pg mL −1 level.