The Separation of Lysergide (LSD) from Related Ergot Alkaloids and Its Identification in Forensic Science Casework Samples
Journal of Forensic Sciences – July 01, 1987
Source: OpenAlex
Summary
Capillary gas chromatography effectively separates lysergide (LSD) from related ergot alkaloids, achieving high discrimination in tests involving 50 LSD microdot tablets and various card and paper samples. Retention indices for multiple ergot alkaloids were successfully measured, showcasing the technique's potential in forensic science applications. In contrast, high-performance liquid chromatography (HPLC) struggled to achieve clear separation between LSD and its isomer, lysergic acid methylpropylamide (LAMPA), highlighting the limitations of HPLC in forensic identification contexts involving illicit substances.
Abstract
Abstract The separation of lysergide (LSD) from related ergot alkaloids, and its isomer lysergic acid methylpropylamide (LAMPA), has been investigated using the techniques of capillary gas chromatography and high performance liquid chromatography (HPLC). Capillary gas chromatography using fused silica nonpolar bonded phase columns gave good discrimination, and retention indices for several ergot alkaloids have been measured. The applicability of this technique to the analysis of illicit LSD preparations has been demonstrated by preparing extracts from LSD microdot tablets and card and paper squares. The HPLC systems examined in the present study were unable to achieve baseline resolution of LSD and LAMPA.