LSD: No Teratogenic Action in Rats, Mice, and Hamsters
Science – August 07, 1970
Source: OpenAlex
Summary
No abortifacient or teratogenic effects were observed in a study involving 98 pregnant rats, 67 mice, and 22 hamsters. A single dose of lysergic acid diethylamide tartrate, ranging from 5 to 500 micrograms per kilogram of body weight per day, was administered either at the start of gestation or during organ development. Examination of 1,003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses showed no significant impact on growth or fetal development, highlighting the compound's safety during pregnancy.
Abstract
Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of body weight per day either at the beginning of gestation or during the period of organogenesis. Examination of the 1003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses obtained failed to prove any abortifacient, teratogenic, or growth-depressing effects.