Simple and Fast Analysis of LSD by Cyclic Voltammetry in Aqueous Medium
ECS Transactions – October 25, 2017
Source: OpenAlex
Summary
A new voltammetric method for detecting LSD offers impressive sensitivity, with detection limits at 0.987 µmol L-1 and quantification limits at 3.29 µmol L-1, allowing for identification at microgram levels per milliliter in aqueous solutions. Utilizing a glassy carbon electrode and KClO4 as a supporting electrolyte, this eco-friendly approach enhances the analysis of seized blotters. Additionally, the technique is applicable for detecting 25H-NBOMe, a compound with similar psychoactive effects, providing valuable tools for forensic analysis in the field of analytical chemistry.
Abstract
The application of electrochemical analysis within the forensic scenario has been widely explored, mainly in the context of the analysis of illicit drugs. In this regard, voltammetric measurements are particularly sensitive and specific. Psychedelic LSD (lysergic acid diethylamide) appears in seized blotters, and its apprehension is constant on a global scale. In this study, we have developed a simple, fast, and sensitive voltammetric method to quantify LSD by using a glassy carbon electrode. The use of an aqueous solution of KClO4 as supporting electrolyte has allowed us to design a less polluting methodology. Concerning the developed method, the anodic peak observed at 0.88 V vs. Ag/AgCl is proportional to the concentration of LSD. The limits of detection and quantification of the method are 0.987 and 3,29 µmol L-1, respectively, which enables detection of LSD at a concentration level of µg per mL of the extraction solution. The same method can also be employed to detect 25H-NBOMe, a compound belonging to the class of NBOMes, which exert practically the same psychoactive effect as LSD.