LSD-Induced Decrease in Serum Prolactin in Rats
Experimental Biology and Medicine – September 01, 1971
Source: OpenAlex
Summary
A 100 μg dose of LSD significantly reduced serum prolactin levels in female rats during proestrus, preventing the expected afternoon increase. In a study involving various doses (25, 50, and 100 μg per 100 g body weight), the highest dose resulted in the most substantial effect, highlighting its potency. The findings suggest that LSD's impact on prolactin mirrors that of other ergot compounds, bridging insights from endocrinology, pharmacology, and internal medicine to explore plant and fungal interactions in chemistry and medicine.
Abstract
SummaryA single ip injection of 25, 50, or 100 μg of LSD (lysergic acid diethylamide)/100 g of body weight into female rats on the morning of proestrus significantly decreased serum prolactin levels, and prevented the normal rise observed in control rats on the afternoon of proestrus. The 100-μg dose of LSD produced a significantly greater decrease in serum prolactin than the 25-μg dose. This action of LSD is shared by other ergot drugs.