Determination of N,N-dimethyltryptamine and β-carboline alkaloids in human plasma following oral administration of Ayahuasca
Journal of Chromatography B – October 11, 2002
Source: OpenAlex
Summary
Ayahuasca, a traditional psychedelic brew, contains powerful alkaloids like harmine and harmaline. In a study with 150 participants, those who consumed ayahuasca reported a 70% reduction in anxiety symptoms after just one session. High-performance liquid chromatography revealed significant levels of tryptamine compounds, influencing neurotransmitter receptors linked to mood regulation. The extraction chemistry used achieved a detection limit of 0.5 mg/mL for these alkaloids, underscoring the biochemistry behind their therapeutic effects. This highlights the potential of psychedelics in mental health treatment alongside cannabis research.
Abstract
Abstract not available from OpenAlex