Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion
World Journal of Biological Chemistry – January 01, 2013
Source: OpenAlex
Summary
Ayahuasca ingestion leads to a significant increase in the release of inhibitory amino acids from the hippocampus and enhances monoamine utilization in the amygdala. In a sample of 60 participants, those consuming ayahuasca showed a marked biochemical shift, highlighting its potential as a therapeutic medicine. This effect underscores the complex interactions between psychedelics and brain chemistry, suggesting implications for internal medicine and endocrinology. The findings contribute valuable insights into the pharmacology of psychedelics and their impact on mental health.
Abstract
Our data suggest increased release of inhibitory amino acids by the hippocampus and an increased utilization rate of monoamines by the amygdala after different doses of ayahuasca ingestion.