Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
Frontiers in Behavioral Neuroscience – June 11, 2021
Source: OpenAlex
Summary
Marmosets, primarily monogamous and living in stable social groups, show social bonds akin to humans, making them valuable for studying social stress-related disorders. In a sample of juvenile marmosets, positive outcomes were observed when testing Ayahuasca, a psychedelic brew from the Amazon, as an alternative treatment for major depression. Their adaptability to captivity, coupled with unique traits like twin births and small size, positions them as promising animal models for psychiatric research. This work highlights the intersection of behavioral ecology and clinical psychology.
Abstract
Knowledge of the behavioral ecology of marmosets carried out in their natural habitat associated with the advent of a non-invasive technique for measuring steroid hormones in feces has made a significant contribution to understanding their social relationships and sexual strategies. These studies showed that they are mainly monogamous, live in relatively stable social groups according to a social hierarchy in which females compete and males cooperate, and form social bonds similar to humans, which makes this species a potential animal model to study disorders related to social stress. In addition, laboratory studies observed the expression of behaviors similar to those in nature and deepened the descriptions of their social and reproductive strategies. They also characterized their responses to the challenge using behavioral, cognitive, physiological, and genetic approaches that were sexually dimorphic and influenced by age and social context. These findings, added to some advantages which indicate good adaptation to captivity and the benefits of the birth of twins, small size, and life cycle in comparison to primates of the Old World, led to their use as animal models for validating psychiatric diseases such as major depression. Juvenile marmosets have recently been used to develop a depression model and to test a psychedelic brew called Ayahuasca from the Amazon rainforest as an alternative treatment for major depression, for which positive results have been found which encourage further studies in adolescents. Therefore, we will review the experimental evidence obtained so far and discuss the extension of the marmoset as an animal model for depression.