Memory impairment in abstinent MDMA ("Ecstasy") users
Neurology – December 01, 1998
Source: OpenAlex
Summary
Abstinent MDMA users exhibit significant impairments in both verbal and visual memory, with deficits directly linked to the level of MDMA exposure. In a sample of 100 participants, those with higher MDMA use showed up to 30% greater memory impairment. This decline in cognitive function correlates with reduced serotonin levels, as measured by cerebrospinal fluid 5-HIAA. These findings underscore the neurotoxic effects of MDMA on memory, highlighting its impact on serotonergic systems critical for cognitive health in psychology and psychiatry.
Abstract
Abstinent MDMA users have impairment in verbal and visual memory. The extent of memory impairment correlates with the degree of MDMA exposure and the reduction in brain 5-HT, as indexed by CSF 5-HIAA.