MDMA polydrug users show processspecific central executive impairments coupled with impaired social and emotional judgement processes
Journal of Psychopharmacology – March 30, 2006
Source: OpenAlex
Summary
MDMA users exhibit significant cognitive impairments, particularly in set shifting and memory updating tasks, impacting their social and emotional judgment. In a study involving 30 participants—15 MDMA users and 15 non-users—results showed that while both groups completed drug use questionnaires, the MDMA group struggled more with tasks assessing executive functions. Notably, deficits in social and emotional judgment persisted even after accounting for other drug use, highlighting potential risks associated with recreational ecstasy consumption on prefrontal cortex-mediated processes.
Abstract
In recent years working memory de.cits have been reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess the impact of MDMA use on three separate central executive processes (set shifting, inhibition and memory updating) and also on ëprefrontalí mediated social and emotional judgement processes. Fifteen polydrug ecstasy users and 15 polydrug non-ecstasy user controls completed a general drug use questionnaire, the Brixton Spatial Anticipation task (set shifting), Backward Digit Span procedure (memory updating), Inhibition of Return (inhibition), an emotional intelligence scale, the Tromso Social Intelligence Scale and the Dysexecutive Questionnaire (DEX). Compared with MDMA-free polydrug controls, MDMA polydrug users showed impairments in set shifting and memory updating, and also in social and emotional judgement processes. The latter two de.cits remained signi.cant after controlling for other drug use. These data lend further support to the proposal that cognitive processes mediated by the prefrontal cortex may be impaired by recreational ecstasy use.