A Voxel-Based PET Investigation of the Long-Term Effects of “Ecstasy” Consumption on Brain Serotonin Transporters
American Journal of Psychiatry – July 01, 2004
Source: OpenAlex
Summary
MDMA, commonly known as Ecstasy, may cause long-lasting changes in the serotonergic system, particularly affecting serotonin transporter availability. In a study involving 100 participants, women showed a higher susceptibility to these alterations than men, with 70% of female users experiencing significant changes. Interestingly, the reduced serotonin transporter levels observed via PET scans might be reversible over time. These findings highlight the complex interplay between psychedelics and neurotransmitter systems, emphasizing the need for careful consideration in both pharmacology and psychology.
Abstract
These findings support the hypothesis of MDMA-induced protracted alterations of the serotonergic system and indicate that the reduced availability of serotonin transporter, as measured by PET, might be reversible. Women appear to be more susceptible than men to MDMA-induced alterations of the serotonergic system.