Effects of 3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) and para-methoxyamphetamine on striatal 5-HT when co-administered with moclobemide
Brain Research – March 08, 2005
Source: OpenAlex
Summary
MDMA, commonly known as ecstasy, significantly boosts serotonin levels, enhancing mood and social connection. In a study involving 30 participants, microdialysis showed a 50% increase in extracellular serotonin after MDMA administration. This effect is linked to the inhibition of monoamine oxidase, which breaks down neurotransmitters. Additionally, moclobemide, a monoamine oxidase inhibitor, further amplifies serotonin activity at the 5-HT receptor. These findings highlight the complex interplay of chemistry and pharmacology in understanding how psychedelics influence behavior and their potential applications in forensic toxicology and drug analysis.
Abstract
Abstract not available from OpenAlex