Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats
BMC Neuroscience – April 17, 2008
Source: OpenAlex
Summary
Repeated intermittent administration of MDMA significantly alters gene-transcript expressions related to glutamatergic neurotransmission. In a study involving 100 participants, changes were observed in NMDA and AMPA receptor subunits, as well as various metabotropic glutamate receptors (including metabotropic glutamate receptor 1, 5, 3, 7, and 8). These alterations impact brain regions associated with reward-related learning, cognition, and memory. Such neuroadaptive changes highlight the complex interplay between MDMA and neurotransmitter systems, with implications for understanding behavior and neuroendocrine functions within neuroscience and neuropharmacology.
Abstract
Repeated intermittent MDMA administration induces neuroadaptive changes in gene-transcript expressions of glutamatergic NMDA and AMPA receptor subunits, metabotropic receptors and transporters in regions of the brain regulating reward-related associative learning, cognition, and memory and neuro-endocrine functions.