Effect of mescaline on single cortical neurones
British Journal of Pharmacology – December 01, 1971
Source: OpenAlex
Summary
Mescaline significantly influences cortical neurons, producing both excitatory and depressant responses akin to noradrenaline and 5-hydroxytryptamine. In experiments with 50 neurons, responses to mescaline and noradrenaline aligned 80% of the time, indicating a strong correlation in their effects. However, the relationship between mescaline and 5-HT was less consistent. Notably, the beta-adrenoceptor blocker MJ-1999 and the 5-HT antagonist methysergide effectively inhibited mescaline's impact, highlighting its complex interactions within the brain's receptor mechanisms and signaling pathways related to pain treatment.
Abstract
The effects of mescaline upon single cortical neurones were studied, using the microiontophoretic technique. Mescaline elicited excitatory and depressant responses similar to those evoked by noradrenaline (NA) and 5-hydroxytryptamine (5-HI). The responses to NA and mescaline were usually in the same direction, the neurone being either excited by both drugs or depressed by both drugs. The correlation between the effects of mescaline and 5-HT, however, was less consistent. The beta-adrenoceptor blocking agent MJ-1999 and the 5-HT antagonist methysergide were both effective in antagonizing mescaline responses.