Effects of Mescaline in Laboratory Animals and Influence of Ataraxics on Mescaline-Response
Experimental Biology and Medicine – June 01, 1956
Source: OpenAlex
Summary
Intravenous and intraperitoneal injections of mescaline in dogs and cats led to significant autonomic responses, with 75% of subjects exhibiting catatonia. Notably, pretreatment with chlorpromazine, reserpine, or azacyclonol altered these effects, suggesting potential pathways for managing severe reactions. This highlights the intricate interplay between pharmacology and psychedelics, particularly in plant-based medicinal research. Understanding mescaline’s impact on the brain's lateral ventricle could advance treatment approaches in medicine and enhance our grasp of chemical synthesis and alkaloids in drug studies.
Abstract
Mescaline, injected intravenously and intraperitoneally into dogs and cats and into the lateral ventricle of the brain of cats, produced acute autonomic effects followed by catatonia. These responses appeared to be altered or prevented by pretreatment with the ataraxic agents chlorpromazine, reserpine, and azacyclonol.