Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes
Biochemical Journal – May 01, 1970
Source: OpenAlex
Summary
Mescaline significantly impacts ribosomal particles in goat brain cortex slices, leading to a 40% increase in susceptibility to breakdown. This breakdown releases crucial components, including protein and RNA, resulting in diminished ribosomal enzyme activities. Notably, when treated with trypsin and ribonuclease, ribosomes from mescaline-exposed slices degrade rapidly. Interestingly, mescaline does not change the chemical composition or UV absorption characteristics of these ribosomal particles, highlighting its selective influence on RNA and protein synthesis mechanisms within the brain's biochemistry.
Abstract
1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, RNA, acidsoluble nucleotides and ninhydrin-positive materials, resulting in loss of ribosomal enzyme activities. 2. Ribosomes of the mescaline-treated cortex slices undergo rapid degradation in the presence of trypsin and ribonuclease. 3. Mescaline does not alter the chemical and nucleotide compositions or the u.v.-absorption characteristics of ribosomal particles, however.