A COMPARISON OF THE EFFECT OF MESCALINE ON ACTIVITY AND EMOTIONAL DEFAECATION IN SEVEN STRAINS OF MICE
British Journal of Pharmacology – September 01, 1975
Source: OpenAlex
Summary
Mescaline significantly reduced emotional defecation while increasing open field activity in male mice from five out of seven genetically diverse strains, with 35 mg/kg body weight administered. Mice from strains A2G, C3H/He, C57BR/cd, CBA/Cam, and F/St exhibited these responses, while strains ICFW and Schneider did not. Notably, a positive correlation emerged between the baseline emotional defecation in saline controls and mescaline's inhibitory effect. Tranylcypromine pre-treatment at 20 mg/kg showed no impact on emotional defecation or its suppression by mescaline.
Abstract
Mescaline hemi‐sulphate (35 mg/kg body weight) was injected intraperitoneally into male mice ( Mus musculus ) from seven genetically diverse laboratory strains. The effect of mescaline was found by comparison of the emotional defaecation and open field activity of mice after mescaline injection with the performance of the same mice after a subsequent saline (0.9% w/v NaCl solution) control injection. In strains A2G, C3H/He, C57BR/cd, CBA/Cam and F/St, mescaline inhibited emotional defaecation and stimulated open field activity. These effects did not occur in strains ICFW and Schneider. A positive relationship was found between the degree of emotional defaecation characteristic of each strain in the saline control experiment and the inhibitory effect of mescaline on emotional defaecation. Pre‐treatment of mice with tranylcypromine (20 mg/kg body weight, i.p.) had no effect on emotional defaecation or on its inhibition by mescaline.