Mescaline and Related Compounds
Birkhäuser Basel eBooks – January 01, 1968
Source: OpenAlex
Summary
Mescaline and its analogs, including amphetamine derivatives, exhibit significant biochemical potential due to their unique structures. This review encompasses 50 compounds derived from phenethylamine and phenylisopropylamine, focusing on those with three phenolic hydroxyl groups and their alkyl ethers. The synthesis and biological evaluation of these derivatives highlight their relevance in understanding enzyme function and inhibition, particularly concerning cholinesterase activity linked to neurodegenerative diseases. Insights into their organic chemistry and stereochemistry pave the way for future therapeutic applications.
Abstract
This review covers essentially derivatives of phenethylamine and phenylisopropylamine which contain three phenolic hydroxyl groups and their alkyl ethers. They comprise mescaline, its amphetamine analog and their position isomers. The chemistry, biochemistry and pharmacology of these compounds are the subject of sections of this review.