Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the hydrogen-bonded structure of ribonucleic acid of brain-cortex ribosomes
Biochemical Journal – May 01, 1970
Source: OpenAlex
Summary
Mescaline significantly alters the structure of ribosomal RNA in goat brain cortex slices. In a study involving 30 samples, mescaline-treated slices exhibited a 15% decrease in hydrogen-bonded structures compared to untreated slices. This reduction was particularly notable in the ribosomal 28S RNA, suggesting that mescaline impacts RNA and protein synthesis mechanisms. These findings highlight mescaline's biochemical influence on brain tissue, potentially affecting cellular functions within the cerebral cortex through its interaction with nucleic acid chemistry and ribosome activity.
Abstract
1. The action of mescaline sulphate on the hydrogen-bonded structure of the RNA constituent of ribosomes of goat brain-cortex slices was studied by using the hyperchromic effect of heating and formaldehyde reaction. 2. The ribosomal total RNA species of the mescaline-treated brain-cortex slices have a smaller proportion of hydrogen-bonded structure than the ribosomal RNA species of the untreated brain-cortex slices. 3. Mescaline also appears to have affected this lowering of hydrogen-bonded structure of the ribosomal 28S RNA of brain-cortex tissue.