Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions.
Experimental Biology and Medicine – January 01, 1956
Source: OpenAlex
Summary
Chlorpromazine and reserpine effectively reduce serotonin-induced uterine contractions in spayed rats, with reserpine showing a longer duration of effect. Specifically, reserpine (0.4 mg/1) outlasts chlorpromazine (0.1 mg/1), while Frenquel (0.8 mg/1) has the shortest impact. Mescaline (0.1 mg/1) enhances serotonin activity and can induce contractions at higher doses, but is unaffected by atropine (0.24 mg/1). Notably, high concentrations of LSD (1 γ/1) inhibit both serotonin and mescaline's effects, whereas lower doses (0.05 to 0.2 γ/1) boost them.
Abstract
SummaryTranquilizing drugs: Frenquel (0.8 mg/1), chlorpromazine (0.1 mg/1) and reserpine (0.4 mg/1), antagonize serotonin-induced uterine contractions, though they do not affect sensitivity of the uterus of the spayed rat either to ACh or oxytocin. The period of antagonism is longer lasting with reserpine than with chlorpromazine and is shortest with Frenquel. Mescaline (0.1 mg/1) causes a facilitation of serotonin activity, and in highest amounts causes a uterine contraction by itself. However, it is not antagonized by atropine (0.24 mg/1). A relatively high concentration of LSD (1 γ/1) antagonizes both serotonin and mescaline-induced uterine activity. In contrast low concentrations of LSD (0.05 to 0.2 γ/1) facilitate the effects of serotonin and of mescaline on the rat uterus.