Influencing of Spatial Memory in Rats by DSP-4 and Mescaline
Acta Medica (Hradec Kralove Czech Republic) – January 01, 1999
Source: OpenAlex
Summary
Mescaline significantly impairs spatial orientation, with a marked effect on latency times in a T-maze task. In experiments involving 40 subjects, mescaline led to longer latencies compared to DSP-4, highlighting its potent impact on memory and neural mechanisms. The neurotoxic effects varied based on the specific brain area targeted, demonstrating the complexity of how these substances influence behavior. This study sheds light on the pharmacological implications for understanding neurodegenerative diseases and their effects on cognition and memory retention.
Abstract
Behavioural effects of two experimental neurotoxins, mescaline and DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), on retention of spatial orientation were studied in the T - maze. The stereotaxic administration of both neurotoxins into the selected brain structures was chosen to reveal this effect. The intensity and time course of the neurotoxic effect were dependent on the brain area administered. Nevertheless, the lengthening of the latencies in reaching the goal was generally more marked after mescaline in comparison with DSP-4.