Bioassay of Ataractics Against Lethal Action of Mescaline in Mice
Experimental Biology and Medicine – July 01, 1958
Source: OpenAlex
Summary
Chlorpromazine, perphenazine, and promethazine significantly reduced mescaline-induced mortality in CF1 mice, showcasing their potential as effective antagonists. In a controlled study with CF1 mice, these medications demonstrated notable protective effects, while others like sodium phenobarbital and meprobamate showed no significant benefits. The results suggest that the protective mechanisms of these drugs operate centrally within the nervous system. This highlights the importance of understanding neurotransmitter receptor influences on behavior and opens avenues for plant-based medicinal research in neuropharmacology.
Abstract
1. It has been demonstrated that chlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine and reserpine are effective antagonists of mescaline-induced mortality in CF1 mice. 2. No significant protection was found with use of sodium phenobarbital, meprobamate, benactyzine, atropine, hydroxyzine, ethoxybutamoxane, SY-21, diphenylhydantoin, trimethadione, lysergic acid diethylamide, serotonin, amphetamine, morphine, pyrilamine, diphenhydramine, iproniazid, pilocarpine, and arecoline. 3. It is suggested that the protective effects of the ataractics against mescalineinduced mortality are centrally mediated.