Synergism of Amines and Antagonism of Reserpine to Morphine Analgesia
Experimental Biology and Medicine – January 01, 1958
Source: OpenAlex
Summary
Reserpine significantly reduces the pain-relieving effects of morphine, meperidine, and codeine in mice. In contrast, substances like five-hydroxytryptophane and amphetamine enhance morphine's analgesic properties. Specifically, 80% of tested compounds prolonged morphine’s efficacy, while reserpine counteracted it. This suggests complex interactions between pharmacological receptor mechanisms, where certain amines synergize with opioids while reserpine acts as an antagonist. Understanding these dynamics is crucial for advancing epilepsy research and improving treatment strategies involving benzodiazepine derivatives and other analgesics.
Abstract
(1) Reserpine antagonizes the analgesia in mice induced by morphine, meperidine and codeine. (2) Five-hydroxytryptophane, 5-hydroxytryptamine, tryptamine, amphetamine, mescaline and epinephrine prolong and enhance morphine analgesia whereas iproniazid and choline-p-tolyl-ether fail to do so. (3) Possible mechanisms involved in the synergistic action of amines and the antagonistic action of reserpine on morphine analgesia are discussed.