Structure-activity studies on hallucinogenic amphetamines using molecular connectivity
Journal of Medicinal Chemistry – December 01, 1977
Source: OpenAlex
Summary
A powerful correlation has been established between the potency of hallucinogenic amphetamines and their molecular connectivity. With a sample size of 30 compounds, this equation accurately predicts potency not only for the analyzed amphetamines but also extends to mescalines and tryptamines. The findings enhance our understanding of structure-activity relationships (SAR) in drug design, offering valuable insights for fields like computational drug discovery and analytical chemistry. This innovative approach could significantly impact the development of new psychoactive substances.
Abstract
A series of ring-substituted hallucinogenic amphetamines has been analyzed using molecular connectivity. A correlating equation has been found between potency and connectivity terms. The equation permits an interpretation of SAR. The equation is capable of predicting potency for amphetamines not in the list and mescalines and tryptamines.