Clinical pharmacology of phencyclidine toxicity
American Journal of Psychiatry – November 01, 1977
Source: OpenAlex
Summary
Phencyclidine (PCP) shows distinct effects compared to other psychedelics like LSD and mescaline, with less influence from individual personality traits. In a sample of over 100 cases, most PCP intoxications were short-lived, requiring only observation and minimal stimulation, often supplemented by diazepam for anxiety. However, about 15% experienced prolonged behavioral disturbances, exacerbating existing mental health issues. Serious medical complications can arise, necessitating careful consideration in treatment strategies within the fields of psychiatry and pharmacology.
Abstract
Phencyclidine appears to be unique in action compared with other psychedelic drugs, and its effects are less dependent upon the individual's personality than are the effects of LSD or mescaline. The authors discuss the sensory, psychological, and behavioral symptoms of phencyclidine intoxication. Most cases are of short duration and the only treatment necessary may be observation together with minimal stimulation and diazepam. However, prolonged and severe behavioral disturbances, exaggeration of preexisting thought disorder, and serious medical complications commonly occur and must be considered in the treatment plan.